The Molecular and Cellular Basis of Neurodegenerative Diseases —— Underlying Mechanisms

----- 神经退行性疾病的分子和细胞基础

ISBN: 9780128113042 出版年：2018 页码：561 Academic Press_RM

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer, Parkinson, frontotemporal dementia, ALS, Huntington, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular featuresFocuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegenerationDetails features, advantages and limitations of animal models, as well as prospects for therapeutic developmentAuthored by internationally recognized leaders in the fieldIncludes illustrations that help clarify and consolidate complex concepts