Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection. For easy reference, the most commonly studied parasites are examined in individual chapters written by investigators at the forefront of their field. An overview of the immune system, as well as introductions to protozoan and helminth parasites, is included to guide background reading. A historical perspective of the field of immunoparasitology acknowledges the contributions of investigators who have been instrumental in developing this field of research.
Emerging protozoan pathogens, once thought to be an obscure menace of society, have become a major threat to human health. The last two decades have seen major advances in the understanding of these increasingly important pathogens.Emerging Protozoan Pathogensprovides a comprehensive account of up-to-date information on the present status of research in this discipline. Written by experts in their respective subject areas, this book provides a valuable resource for microbiologists and molecular and cell biologists at advanced undergraduate and graduate levels, as well as health professionals and researchers who are interested in these pathogens. The material covered, includingbiology, genomics, epidemiology, pathogenesis and treatments, makes it an ideal platform on which to base further research projects.
Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Includes information on the basic biology and function of proteases Provides global survey of current research efforts in protease inhibitors Illustrates how structure-based drug design targets effective and selective compounds Highlights important diseases that provide economically important targets Describes the role of proteases as important new targets for drug discovery
Antibiotics
Immunology of Infection, 3e, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in analyzing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes" and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
Sexually transmitted infections (STIs) are a heterogeneous group of communicable diseases, whose only common element is sharing of sexual route as a mechanism of acquisition. With nearly 450 million cases detected annually, STIs represent a priority health problem worldwide, because of the impact they have on the physical and mental health of people who suffer, as the complications and consequences that can result and their relation to increased transmissibility of human immunodeficiency virus (HIV) infection. Clinical manifestations, in most cases, involve the genital area and mucous but sometimes, cause systemic affectation. Infection due to Chlamydia trachomatis is already the most frequent STI of global health significance. Its epidemiological interest has increased markedly in recent years because the majority of infections run an asymptomatic course which can lead to serious complications, especially in young women. This book discusses the prevalence, pathogenesis and the prevention of chlamydia.
Written by international experts, this book reviews recent, cutting-edge research on the use of immunoregulatory probiotics (immunobiotics) and their bioactive compounds (immunogenics) to prevent disease and improve health. Each chapter provides critical insight, reviews current research, discusses future perspective, and stimulates discussion. The
This concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease.The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific
This work details current medical uses of antiseptics and disinfectants, particularly in the control of hospital-acquired infections. It presents methods for evaluating products to obtain regulatory approval, and examines chemical, physical and microbiological properties as well as the toxicology of the most widely-used commercial chemicals. Formul
Pseudomonas aeruginosa is a unique pathogen with a characteristic hospital epidemiology resulting in colonization and major infectious complications. Institutions of infection control policies including guidelines on surveillance, infection control interventions and environmental decontamination are important preventive measures. In this book, the authors present current research on the symptoms of infection, antibiotic resistance and treatment of pseudomonas aeruginosa. Topics discussed include the mechanisms of antimicrobial resistance and antimicrobial treatment options; chronic pseudomonas aeruginosa infection in cystic fibrosis; and biofilm-forming ability and antimicrobial resistance of pseudomonas aeruginosa isolates of veterinary origin.
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