In these, (2) and (12) are directly from the definitions; the others may be separated into 4 sets of 4 each, such that when one member of each set is calculated directly, the others follow from it by successive doubling and reduction. Thus.
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Toxoplasma gondii is an obligate intracellular parasite that infects 10-20% of the overall population in the US with rates increasing with age. T. gondii infects most warm blooded animals where an antibody response is generated to control the infection, however, the parasite forms bradyzoite cysts in brain and muscle. It can only reproduce in felines where oocytes are excreted in the feces. Infection can occur by a variety of routes. In cats, infection occurs by eating infected prey, primarily rodents or birds. Infection in humans can occur by eating undercooked infected meat, handling infected cat feces, ingesting oocytes on unwashed fruits or vegetables, or drinking contaminated water. Another important route of infection is congenital infection. This book discusses the potential risks this parasitic infection may cause. It also reviews the parasite's life cycle.
A role for triterpenes in the cancer setting is gradually emerging. Bringing together the efforts of both academy and industry, this book highlights the most significant research results achieved with pentacyclic triterpenic compounds, providing clues for lead compound selection and targets to be exploited. It will work as an extension of the continuous discussion concerning the introduction of these agents into the clinical setting for chemotherapy and chemoprevention purposes.
Malaria is one of the most prevalent infectious diseases worldwide. Severe malaria leads to the death of close to two million individuals every year. Plasmodium falciparum, the causative agent of the most severe form of malaria is becoming increasingly resistant to current drugs, including artemisinin. This book presents current advances and comprehensive material in the biology of the parasite responsible for the most enduring and devastating disease of mankind. This book addresses P. falciparum infection and severe malaria, the role of heat shock proteins in the development and pathogenicity of the parasite, the biosynthesis of isoprenoid, specifically the methylerythritol phosphate (MEP) pathway in the erythrocytic stages of the parasite is described.
Advances in Pharmacology and Therapeutics, Volume 3: Ions ?Cyclic Nucleotides ?Cholinergy covers the proceedings of the Seventh International Congress of Pharmacology, held in Paris in 1978. This book mainly focuses on studying ions, cyclic nucleotides, and cholinergy. Specifically, this text discusses the pharmacology of calcium homeostasis and presents lectures given in the symposium. The role of cyclic nucleotides in the regulation of muscular tissue functions and the evaluation of cyclic AMP and cyclic GMP are also looked into. This text presents in its latter part papers on chemical structure and cholinergic activity. This volume will be valuable to students and experts in the field of pharmacology, therapeutics, and related fields.
Since the days of Diels, Alder and Woodward, cycloadditions have been among the most versatile reactions for stereoselective synthesis ... All relevant information is collected in this well-structured, practical handbook. Arranged according to the cycloaddition type, the suitable auxiliaries, reactants, stereoselectivities, yields, and references for each key reaction are compiled in compact tables. Scientists interested in the theoretical background of stereoselective cycloadditions will find an excellent selection of in-depth literature references. ... with this comprehensive data collection cycloadditions will become an even more powerful tool for every organic chemist working on stereoselective synthesis.
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