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Metabolic engineering
Mass Spectrometry of Inorganic and Organometallic Compounds -- Tools - Techniques - Tips
无机与有机金属化合物的质谱学：工具－技术－诀窍
Wiley William Henderson J Scott McIndoe
ISBN：9780470850169，出版年：2005，中图分类号：O6

This is the first modern book to treat inorganic and organometallic mass spectrometry simultaneously. It is textbook and handbook in one; as a textbook it introduces the techniques and gives hints on how to apply the various techniques, as a handbook it lists all available ionization techniques for just about any given compound. The book also includes non-mathematical explanations of how modern MS instruments work Mass Spectrometry of Inorganic and Organometallic Compounds will inspire the synthetic inorganic and organometallic chemist with the confidence to apply some of the new techniques to their characterization problems.

Microbiological Techniques Combinatorial Chemistry Techniques Metabolic engineering Mechanistic organic photochemistry Molecular diagnostic techniques Microscale chemistry Chemiosmotic Mechanisms Biomechanical engineering Inorganic chemistry Synthesis methods
Metalloproteomics
金属蛋白质组学
Wiley Eugene Permyakov
ISBN：9780470392485，出版年：2009，中图分类号：Q5

Synthesizes the current knowledge in the field and provides new insights into medical applications Metalloproteomics is the large-scale study of metal-binding proteins. These proteins, which represent about one quarter of all the proteins in the Protein Data Bank, play important roles in all biological systems and all biological processes. Metalloproteomics provides the latest information on all major families of metal-binding proteins, including their structural, physico-chemical, and functional properties, enabling readers to better understand these proteins. Moreover, the book demonstrates how understanding the structures, properties, and functions of intracellular and extracellular metal-binding proteins may unlock the key to drug development for the treatment of a myriad of diseases. Written by Eugene Permyakov, an international expert and pioneer in the structural analysis of metal-binding proteins, the book offers Theoretical introduction to cation binding Broad range of methods for investigating the binding of different cations to proteins Characteristics of interactions of physiologically important cations of Ca, Mg, Zn, Fe, Mn, Co, Cu, Ni, Mo, W, Na, and K with proteins Detailed considerations of structural and physico-chemical properties of the metal-binding proteins Interactions of all other metal cations with proteins Interactions of different types of cations with nucleic acids Throughout the text, the author integrates principles of proteomics. In addition, detailed examples underscore the role metal-binding proteins play in health and medicine. Bringing together and analyzing all the latest findings, Metalloproteomics' scope and level of insight are unparalleled. It is recommended for biophysicists, biochemists, enzymologists, cell and molecular biologists, protein and peptide scientists, organic and bioinorganic chemists, and chemical biologists.

Metacystis Metatrichia vesparium Metabolomics Metaphysics Metaplasia Metatheatre Matrix metalloproteases Metamaterial Meontology Metabolic engineering
Metabolic Syndrome -- Underlying Mechanisms and Drug Therapies
代谢综合征：基础机理与药物治疗
Wiley Minghan Wang
ISBN：9780470343425，出版年：2011，中图分类号：R4

This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.

Chemiosmotic Mechanisms Homeostatic mechanism Metabolic engineering Neoplasm chemotherapy Erythropoietin therapy Diuretics therapy Drug metabolism Metabolic alkaloses Diuretics treatment Tratamiento farmacologico
Pathway Analysis and Optimization in Metabolic Engineering
路径分析与代谢工程的最优化
Cambridge University Press Nestor V Torres Eberhard O Voit
ISBN：9780521177481，出版年：2002，中图分类号：Q81 被引 257次

Preface 1. Target: a useful model 2. Methods of biochemical systems theory 3. A model of citric acid production in the mold Aspergillus niger 4. Optimization methods 5. Optimization of biochemical systems 6. Optimization of citric acid production in Aspergillus niger 7. Maximization of ethanol and carbohydrate production in Saccharomyces cerevisiae 8. Conclusions Author index Subject index.

Aspergillus niger Biochemical systems theory Metabolic engineering Citric acid Saccharomyces cerevisiae Biology Optimization methods Pathway analysis
Matroid Applications
拟阵的运用
Cambridge University Press Neil White
ISBN：9780521119672，出版年：1992，中图分类号：O1

This volume, the third in a sequence that began with The Theory of Matroids and Combinatorial Geometries, concentrates on the applications of matroid theory to a variety of topics from engineering (rigidity and scene analysis), combinatorics (graphs, lattices, codes and designs), topology and operations research (the greedy algorithm). As with its predecessors, the contributors to this volume have written their articles to form a cohesive account so that the result is a volume which will be a valuable reference for research workers.

Methamphetamine use Metamasius hemipterus Metabolic engineering Metatrichia vesparium Medulloblastoma Metabolomics Macular degeneration Mastocytoma Metabolic alkaloses Macrolepiota procera
The Muse Method for Usability Engineering
可用性工程的缪斯方法
Cambridge University Press Kee Yong Lim John B Long
ISBN：9780521479998，出版年：1994，中图分类号：TP3

When this book was first published, recent aspects of human factors research had led to methodologies that integrated usability into the development of interactive systems. MUSE was one of the pioneering methods for Usability Engineering. It provides an environment in which human factors contributions can realise their full potential. MUSE supports active human factors involvement in both design specification and evaluation, and takes system development from user requirements to user interface design. Its methods describe how design errors can be avoided or rectified throughout system development, as well as showing how errors can be identified and providing support for inter-disciplinary design planning and coordination. It therefore ranks as one of the best developed and most completely structured human factors methods. This book reviews the motivation for developing MUSE, and provides readers with a manual for method application. It will be essential reading for all involved with systems development, whether from the HCI or software engineering communities, and can be used as well for course accompaniment.

Method engineering Usability engineering Nelder–Mead method Montessori method Mitrofanoff technique Memetic engineering Trajectory method Good engineering practice Metabolic engineering Construction method
Engineering Complex Phenotypes in Industrial Strains
工业菌株中的工程复合表型
Wiley Ranjan Patnaik
ISBN：9780470610756，出版年：2012，中图分类号：TQ 被引 128次

The global demand is rising for greener manufacturing processes that are cost-competitive and available in a timely manner. This has led to the development of a series of new tools and integrative platforms enabling rapid engineering of complex phenotypes in industrial microbes. By blending "old classical methods" of strain isolation with "newer approaches" of cell engineering, researchers are demonstrating the ability to stack multiple complex phenotypes in industrial hosts with some level of certainty. Newer tools for dissecting the genotype-phenotype correlation include association analysis (Precision Engineering), multiSCale Analysis of Library Enrichment (SCALE) in competition experiments, whole-genome transcriptional analysis, and proteomics and metabolomics technology. These newer and older tools of metabolic engineering and synthetic biology when combined with recent whole cell engineering approaches like whole genome shuffling, global transciptome machinery engineering, and directed evolutionary engineering, provide a powerful platform for engineering complex phenotypes in industrial strains. This review attempts to highlight and compare these newer tools and approaches with traditional strain isolation procedures as it applies to genome engineering with examples taken from literature.

Synthetic biology Genome engineering Precision engineering Metabolic engineering Proteomics Data science Biotechnology Biology Cell engineering Evolutionary engineering Genome shuffling Genetic Engineering methods * Genetic Engineering Genomics methods Genomics Genotype Industrial Microbiology methods * Industrial Microbiology Phenotype Proteomics methods Proteomics
Muscles as Molecular and Metabolic Machines
肌肉作为分子和代谢机器
CRC Press Hochachka, Peter W
ISBN：9780367227807，出版年：2019，中图分类号：Q7

First published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen?To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.

Molecular machine Molecular mass Macromolecule Molecular motor Masseter muscle Chemiosmotic Mechanisms Structural Macromolecules Molecular biophysics Molecular dynamics Metabolic engineering
Metaheuristics for Robotics
机器人的元启发式
Wiley Hamouche Oulhadj Boubaker Daachi
ISBN：9781786303806，出版年：2020，中图分类号：TP2

This book is dedicated to the application of metaheuristic optimization in trajectory generation and control issues in robotics. In this area, as in other fields of application, the algorithmic tools addressed do not require a comprehensive list of eligible solutions to effectively solve an optimization problem. This book investigates how, by reformulating the problems to be solved, it is possible to obtain results by means of metaheuristics. Through concrete examples and case studies – particularly related to robotics – this book outlines the essentials of what is needed to reformulate control laws into concrete optimization data. The resolution approaches implemented – as well as the results obtained – are described in detail, in order to give, as much as possible, an idea of metaheuristics and their performance within the context of their application to robotics.

Robotic excavator Evolutionary robotics Analog robot Soft robotics Robotic surgery Chemiosmotic Mechanisms Mechanobiology Metabolic engineering Memetic engineering Mechanical singularity
Iron Metabolism -- From Molecular Mechanisms to Clinical Consequences
铁代谢:从分子机制到临床效果 第四版
Wiley Robert Crichton
ISBN：9781118925614，出版年：2016，中图分类号：Q5

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems  a natural target for  pathogenic microorganisms and parasites. Uniquely, humans  suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is  associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health.The 4th edition of Iron Metabolism  is written in a lively style by one of the leaders in the field, presented in colour  and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Molecular machine Chemiosmotic Mechanisms Molecular engineering Monosaccharide metabolism Molecular dynamics Molecular biophysics Metabolic engineering Molecular cell biology Molecular biology Carbohydrate Metabolism Disorder
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