Chapter One: Biotechnology And Genomics In Medicine.Introduction.Recombinant DNA Technology.From Recombinant DNA To Molecular Medicine.Gene Medicine.Disease Models.The Impact Of Genomics On Medicine.The New Molecular Medicine.Outline Of This Book.Further Reading.Chapter Two: An Overview Of Genomics.Introduction.A Review Of Progress: The Human Genome Project.The Future: Functional Genomics.Mutational Genomics.Further Reading.Chapter Three: Genomics And The Challenge Of Infectious Disease.Microorganisms Causing Disease.Where Do New Diseases Come From?.Identifying The Causative Agent Of A Disease.Molecular Epidemiology.Host Resistance To Infection.Understanding Bacterial Pathogenicity.Comparative Genomics And Genome Plasticity.Combating Infectious Disease.Further Reading.Chapter Four: Analyzing And Treating Genetic Diseases.Genetic Disease In Context.Detecting Single Gene Disorders.Treating Single Gene Disorders.Finding Genes For Monogenic Diseases And Determining Gene Function.Analysis Of Polygenic Disorders.Haplotypes.The Major Histocompatibility Complex (MHC).Individual Responses To Drugs (Pharmacogenomics).Further Reading.Chapter Five: Diagnosis And Treatment Of Cancer.Introduction.The Impact Of Genomics On Cancer Research.New Methods For The Diagnosis Of Cancer.New Approaches To Cancer Therapy.Further Reading.Chapter Six: The Large Scale Production Of Biopharmaceuticals.Overview.The Generation Of Monoclonal Antibodies.The Large Scale Culture Of Microorganisms.The Large Scale Culture Of Animal Cells.Expression Systems.Downstream Processing.Using Gene Manipulation To Facilitate Downstream Processing. Of Biopharmaceuticals.The Quality Of Biopharmaceuticals.Good Manufacturing Practice.Alternative Production Systems.Further Reading.Chapter Seven: Genomics And The Development Of New Chemical Entities.Introduction. How Drugs Are Developed.High-Throughput Screening.Target Validation And Animal Models.Combinatorial Chemistry.Dynamic Combinatorial Libraries.Virtual Screening.Combinatorial Biosynthesis And Chemobiosynthesis.Drug Metabolism.Toxicogenomics.Further Reading.Chapter Eight: Gene And Cell Therapies.Introduction.Gene Therapy.Nucleic Acids As Drugs.DNA Vaccines.Disease Models.Cell Therapy.Further Reading.
Provides a professional, contemporary, and concise review of the current knowledge and advances in biomimetics This book covers the field of biomimicry, an area of science where researchers look to mimic aspects of plants or animals in order to solve problems in aerospace, shipping, building, electronics, and optics, among others. It presents the latest developments in biomimicry and gives readers sufficient grounding to help them understand the current, and sometimes technically complex, research literature. Different themes are covered throughout and text boxes deal with the relevant physics for readers who may lack this knowledge. Biomimetics: Nature-Inspired Design and Innovation examines issues in fluid dynamics such as avoiding sonic booms, reducing train noise, increasing wind turbine efficiency, and more. Next, it looks at optical applications, e.g. how nature generates color without dyes and pigment, and how animals stay cool in desert environments. A chapter on the built environment discusses cooling systems for buildings based on termite mounds; creating self-cleaning paint based on lotus leaves; unobtrusive solar panels based on ivy; and buildings that respond to the environment. Two more sections focus on biomimicry for the creation of smart materials and smart devices. The book finishes with a look at the field’s future over the next decade. Presents each topic in sufficient detail in order to enable the reader to comprehend the original scientific papers Emphasizes those examples of biomimicry that have made it into products Features text boxes that provide information on the relevant physics or engineering principles for biologists who do not have a physics background Covers the scientific literature up to July 2019 Biomimetics: Nature-Inspired Design and Innovation is an excellent book for senior undergraduates and post-graduate students in the life sciences, material sciences, and bioengineering. It will also appeal to lay readers with an interest in nature as well as scientists in general.
With the first draft of the human genome project in the public domain and full analyses of model genomes now available, the subject matter of 'Principles of Genome Analysis and Genomics' is even 'hotter' now than when the first two editions were published in 1995 and 1998. In the new edition of this very practical guide to the different techniques and theory behind genomes and genome analysis, Sandy Primrose and new author Richard Twyman provide a fresh look at this topic. In the light of recent exciting advancements in the field, the authors have completely revised and rewritten many parts of the new edition with the addition of five new chapters. Aimed at upper level students, it is essential that in this extremely fast moving topic area the text is up to date and relevant. Completely revised new edition of an established textbook. Features new chapters and examples from exciting new research in genomics, including the human genome project. Excellent new co-author in Richard Twyman, also co-author of the new edition of hugely popular Principles of Gene Manipulation. Accompanying web-page to help students deal with this difficult topic at www.blackwellpublishing.com/primrose
The increasing integration between gene manipulation and genomics is embraced in this new book, Principles of Gene Manipulation and Genomics, which brings together for the first time the subjects covered by the best-selling books Principles of Gene Manipulation and Principles of Genome Analysis & Genomics. Comprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics Includes two new chapters on the applications of genomics An accompanying website - www.blackwellpublishing.com/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format. An essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA technology.
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