Early Versus Delayed Enteral Feeding for Achieving Full Feeding —— In Preterm Growth-Restricted Infants: a Randomized Clinical Trial

----- 早期与延迟肠内喂养以实现全量喂养：在生长受限的早产儿中：一项随机临床试验

ISBN: 9786138934929 出版年：2020 页码：108 Farzana Ahmed Scholars' Press

Feeding in growth restricted preterm newborns is extremely challenging & yet there is no consensus regarding how best to prevent feeding intolerance while achieving optimal growth in these vulnerable newborns. So this Randomized clinical Trial was conducted to evaluate the effect of early versus delayed Enteral Feeding for Preterm Growth-Restricted Infants. During the study period, out of 131 infants with small for gestational age, 68 babies were enrolled and randomly assigned to either early feeding group (n=34) or late feeding group (n=34) by computer-based randomization. Newborn enrolled in early feeding group achieved full feeding earlier and experienced less number of feed intolerance than late feeding group (Hazard ratio 0.339; log rank p 0.00, df 1. which indicates early feeding is protective.) Early feeding group regained birth weight faster; experienced lesser incidence of neonatal sepsis, had shorter mean duration of hospital stay and achieved higher weight on post natal age 16th days. All values were statistically significant as p 0.00. Early feeding practice is well tolerated by growth restricted preterm infants.