Prodrugs and Targeted Delivery —— Towards Better ADME Properties

----- 前体药物与靶输送：旨在更佳 ADME 特性

ISBN: 9783527326037 出版年：2011 页码：522 Jarkko Rautio Raimund Mannhold Wiley

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.