Lipases and Phospholipases in Drug Development —— From Biochemistry to Molecular Pharmacology

----- 药物开发中的脂肪酶和磷脂酶

ISBN: 9783527306770 出版年：2006 页码：356 Gunter Muller Stefan Petry Wiley

Preface.List of Contributors.1. Purification of Lipase (P. Vasudevan).2. Phospholipase A1: Structures, Physiological and Patho-physiological Roles in Mammals (K. Inoue, et al.). 3. Rational Design of a Liposomal Drug Delivery System Based on Biophysical Studies of Phospholipase A2 Activity on Model Lipid Membranes (K.Jorgensen, et al.). 4. Phospholipase D (J. Exton).5. Sphingomyelinases and Their Interaction with Membrane Lipids (F. Goni & A. Alonso).6. Glycosyl-phosphatidylinositol Cleavage Products in Signal Transduction (Y. Leon & I. Varela-Nieto).7. High-throughput Screening of Hormone-sensitive Lipase and Subsequent Computer-assisted Compound Optimization (S. Petry, et al.). 8. Endothelial Lipase: A Novel Drug Target for HDL and Atherosclerosis? (K. Badellino, et al.). 9. Digestive Lipases Inhibition: an In vitro Study (A. Tiss, et al.). 10. Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors (H. Lengsfeld, et al.). 11. Physiological and Pharmacological Regulation of Triacylglycerol Storage and Mobilization (G. Muller).Subject Index.