Self-assembled Molecular Structures – New Kind Of Protein Ligand —— Supramolecular Ligands

----- 自组装分子 - 新型蛋白质配体：超分子配体

ISBN: 9783319656380 出版年：2017 页码：42 Roterman, Irena Konieczny, Leszek Springer

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. This book is an open access under a CC BY license.