Endocrine Disruptors and Child Health —— 9th ESPE Advanced Seminar in Developmental Endocrinology, Rome, May 2015. Special Topic Issue: Hormone Research in Paediatrics 2016, Vol. 86, No. 4

----- 内分泌干扰物与儿童健康

ISBN: 9783318059717 出版年：2016 页码：87 S.Karger

Endocrine disruptors are chemicals that may interfere with the body's endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. This issue of Hormone Research in Paediatrics covers their impact on child health. It reviews history, toxicology, epidemiology, pathophysiology, and major clinical implications including the effects on neuroendocrine pathways, growth, obesity, steroidogenesis, puberty timing, and thyroid function. Human exposure to endocrine disruptors occurs via ingestion of food, dust, and water, inhalation of gases and particles in the air, and through the skin. Chemicals can also be transferred from mother to child through the placenta or breast milk. The critical windows of exposure and the transgenerational effects are discussed along with prevention strategies to potentially minimize exposure and reduce risk.