Ultrastructure of Mast Cells and Basophils

ISBN: 9783805578646 出版年：2005 页码：376 Dvorak A M (Boston, MA) S.Karger

Introduction Ultrastructural Analysis Is Necessary and Sufficient for Identification of Basophils and Mast Cells Cyclooxygenase, a Key Enzyme Family for Production of Prostaglandins, Is Present in Human Mast Cell Lipid Bodies Subcellular Localization of the Cytokines, Basic Fibroblast Growth Factor and Tumor Necrosis Factor-[alpha] in Mast Cells Immunogold Ultrastructural Techniques Identify Subcellular Sites of Chymase, Charcot-Leyden Crystal Protein, and Histamine in Basophils and Mast Cells Ultrastructural Enzyme-Affinity-Gold and Inhibitor-Gold Techniques Identify Subcellular Sites of Histamine and Heparin in Basophils and Mast Cells Piecemeal Degranulation of Basophils and Mast Cells Is Effected by Vesicular Transport of Stored Secretory Granule Contents Mast Cell-Derived Mediators of Enhanced Microvascular Permeability, Vascular Permeability Factor/Vascular Endothelial Growth Factor, Histamine, and Serotonin, Cause Leakage of Macromolecules through a New Endothelial Cell Permeability Organelle, the Vesiculo-Vacuolar Organelle Degranulation and Recovery from Degranulation of Basophils and Mast Cells Mast Cell Secretory Granules and Lipid Bodies Contain the Necessary Machinery Important for the in situ Synthesis of Proteins Concluding Statement References Subject Index.