Mismatch Negativity —— Special Topic Issue: Audiology and Neuro-Otology 2000, Vol. 5, No. 3-4

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ISBN: 9783805571005 出版年：2000 页码：149 S.Karger

This publication gives a state-of-the-art review on the use of the mismatch negativity (MMN) brain response, the only objective index of sound-discrimination accuracy in assessing the central auditory function in normals and in several pathological conditions. Because of its attention- and task-independent elicitation, MMN can be used to study the central auditory function of patients and infants who cannot perform behavioral tasks properly. Thus, MMN can, for example, be used to identify speech-perception problems in newborns and infants well before they manifest themselves in the form of speech delay. MMN can also be used to predict coma outcome, to estimate the function of cochlear prostheses, to evaluate the pathology of auditory processing in schizophrenia, neurodegenerative diseases and aging, to assess the attentional damage in unilateral neglect after right-hemisphere damages, and to ascertain the distractibility by irrelevant auditory stimulation in normals and several clinical patient groups. The special issue closes with a state-of-the-art discussion on the different methodological aspects of the use of MMN both in research and in the clinic.