Protein Metabolism in Renal Diseases —— Special Topic Issue: Mineral and Electrolyte Metabolism 1998, Vol. 24, No. 1

----- 肾脏疾病的蛋白质代谢

ISBN: 9783805565738 出版年：1997 页码：101 S.Karger

In this issue of 'Mineral and Electrolyte Metabolism' an international group of experts summarizes our current knowledge of the influence of the spectrum of renal diseases on nutritional status and highlights areas for future research. It begins with a review of the normal physiologic responses to alterations in protein intake and evidence that activation of specific intracellular pathways is responsible for increased protein and amino acid degradation in many pathologic states, including uremia. The impact of malnutrition on kidney function and the alterations in protein and amino acid metabolism induced by various renal diseases and dialysis are reviewed. The benefits of prescribing low protein diets to treat patients with chronic renal failure are discussed. Guidelines for assessing nutritional status are provided and therapeutic interventions to promote anabolism in malnourished renal patients are summarized. The impact of nutritional status on patient outcomes is reviewed and recent evidence that hypoalbuminemia in dialysis patients is more closely related to 'inflammation' than to dietary intake is discussed. This publication provides an up-to-date review of the impact of renal disease on nutritional status and is directed towards the practicing nephrologist, subspecialty trainee as well as dieticians managing patients with kidney disease.