Apolipoproteins: Regulatory Functions, Health Effects and Role in Disease

ISBN: 9781622574988 出版年：2012 页码：166 Adrik D Sidorov Misha Y Nikitin Nova Science

Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport the lipids through the lymphatic and circulatory systems. Apolipoproteins also serve as enzyme cofactors, receptor ligands, and lipid transfer carriers that regulate the metabolism of lipoproteins and their uptake in tissues. In this book, the authors present current research in the study of the regulatory functions, health effects and role in disease of apolipoproteins. Topics include macrophages, apolipoproteins, steroid hormones and molecular mechanisms of cell proliferation; formation of discoidal apolipoprotein A-1 lipid bound complexes; the role of apolipoprotein E in cardiovascular and renal disease; the functional variants and mutations of the apolipoprotein A5 gene in human pathology; and regulation of FGF-1 of ApoE/HDL generation in astrocytes.