Introduction to Statistical Methods in Modern Genetics

ISBN: 9780367398903 出版年：2000 页码：258 Yang, M C CRC Press

BACKGROUND TO MODERN STATISTICAL GENETICS Introduction: Where is the Gene? Function of Genes in Reproduction Some Facts in Molecular Genetics Tools in Molecular Genetics Genetic Engineering Exercise 1 LINKAGE ANALYSIS WITH QUALITATIVE TRAIT Basic Concepts in Pedigree Analysis Linkage analysis for Large Pedigrees Incomplete Penetrance and Sibling Studies Designs in Linkage Analysis Exercise 2 GENETICS OF QUANTITATIVE TRAIT Quantitative Trait Locus (QTL) Based on Sibpairs Interval Mapping of Quantitative Trait Loci Heritability Estimation Breeding Value Evaluation Models Exercise 3 SPECIAL TOPICS Small Area Gene Mapping by Linkage Disequilibrium Gene, Exon, and Intron Identification Reconstruction of Evolutionary Path Forensic Evidence Using Genetic Markers Exercise 4 APPENDIX A: STATISTICAL RESULTS USEFUL IN GENETICS Multivariate Analysis and Regression Likelihood Ratio Test and General Linear Models Multinomial Distribution Inference on Frequency Tables Discriminant Analysis and Neural Network APPENDIX B: SELECTED PUBLIC DOMAIN COMPUTER PROGRAMS FOR GENETIC DATA ANALYSIS A Teaching Linkage Analysis Program for Two Generation Families A Simulation Program to Computer ELOD and Var(LOD) for Two Generation Families Liped and Programs Described in Terwilliger and Ott's Handbook Simlink - Power Prediction for Given Pedigress SIB-PAIR A Nonparametric Linkage Software MAPMAKER/SIBS, MAPMAKER/QTL, Genehunter, GAS A SAS Program to Computer Kinships Coefficients Using SAS-IML to Solve Handerson's Equation ETDT GeneBank and Genetic Data Sources Answers or Hints to Exercises Bibliography