Randomized Phase II Cancer Clinical Trials

ISBN: 9781439871850 出版年：2013 页码：236 Jung, Sin-Ho CRC Press

In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biosta