Micro Reaction Technology in Organic Synthesis

ISBN: 9781439824719 出版年：2016 页码：456 Wiles, Charlotte Watts, Paul CRC Press

Introduction to Micro Reaction Technology What is Micro Reaction Technology? Fabrication/Construction of Micro Reactors Manipulation of Reactants and Products within Flow Reactors Advantages of Micro Reaction Technology Disadvantages of Micro Reactors Process Intensification In Situ Reaction Monitoring Commercial Availability of Continuous Flow Outlook References Micro Reactions Employing a Gaseous Component Gas-Phase Micro Reactions Gas-Liquid-Phase Micro Reactions Gas-Liquid-Solid Micro Reactions References Liquid-Phase Micro Reactions Nucleophilic Substitution Electrophilic Substitution Nucleophilic Addition Elimination Reactions Oxidations Reductions Metal-Catalyzed Cross-Coupling Reactions Rearrangements Multistep/Multicomponent Liquid-Phase Reactions Summary References Multi-Phase Micro Reactions Nucleophilic Substitution Electrophilic Substitution Nucleophilic Addition Elimination Reactions Oxidation Reactions Metal-Catalyzed Cross-Coupling Reactions Rearrangements Enantioselective Reactions Multistep/Multicomponent Reactions Summary References Electrochemical and Photochemical Applications of Micro Reaction Technology Electrochemical Synthesis under Continuous Flow Photochemical Synthesis under Continuous Flow Multiphase Photochemical Reactions References The Use of Microfluidic Devices for the Preparation and Manipulation of Droplets and Inorganic/Organic Particles Droplet Formation using Continuous Flow Methodology Preparation of Inorganic Nanoparticles under Continuous Processing Conditions Formation of Organic Particles within Continuous Flow Devices The Use of Micro Reactors for the Postsynthetic Manipulation of Organic Compounds Mixed Particle Formation Summary References Industrial Interest in Micro Reaction Technology MRT in Production Environments Synthesis of Fine Chemicals Using Micro Reactors Synthesis of Pharmaceuticals and Natural Products using Continuous Flow Methodology Synthesis of Small Doses of Radiopharmaceuticals Summary References Microscale Continuous Separations and Purifications Introduction Liquid-Liquid Extractions Gas-Liquid Separation Solvent Exchange and Solvent Removal The Use of Scavenger Resins for Product Purification under Flow Continuous Flow Resolutions Product Isolation Summary References