Anticancer Agents from Natural Products

ISBN: 9781439813829 出版年：2011 页码：762 CRC Press

Introduction Gordon M. Cragg, David G. I. Kingston, and David J. Newman Camptothecin and Its Analogs Nicolas J. Rahier, Craig J. Thomas, and Sidney M. Hecht The Discovery and Development of the Combretastatins Kevin G. Pinney, George R. Pettit, Mary Lynn Trawick, Christopher Jelinek, and David J. Chaplin Homoharringtonine and Related Compounds Hideji Itokawa, Yukio Hitotsuyanagi, and Kuo-Hsiung Lee Podophyllotoxins and Analogs Kuo-Hsiung Lee and Zhiyan Xiao Taxol and its Analogs David G. I. Kingston The Vinca Alkaloids Fanny Roussi, Francoise Gueritte, and Jacques Fahy The Bryostatins David J. Newman The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins Rima S. Al-awar and Chuan Shih Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons Sarath P. Gunasekera and Amy E. Wright The Dolastatins: Novel Antitumor Agents from Dolabella auricularia Erik Flahive and Jayaram Srirangam Ecteinascidin-743 (Yondelis(R)), Aplidin(R), and Irvalec(R) Carmen Cuevas, Andres Francesch, Carlos M. Galmarini, Pablo Aviles, and Simon Munt Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B Melvin J. Yu, Yoshito Kishi, and Bruce A. Littlefield HTI-286 (Taltobulin), A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin Raymond J. Andersen, David E. Williams, Wendy K. Strangman, and Michel Roberge The Actinomycins Anthony B. Mauger and Helmut Lackner Anthracyclines Federico-Maria Arcamone Ansamitocins (Maytansinoids) Tin-Wein Yu, Heinz G. Floss, Gordon M. Cragg, and David J. Newman Benzoquinone Ansamycins Kenneth M. Snader Bleomycin Group Antitumor Agents Sidney M. Hecht Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides Rohtash Kumar and J. William Lown Epothilone, a Myxobacterial Metabolite With Promising Antitumor Activity Gerhard Hofle and Hans Reichenbach Enediynes Philip R. Hamann, Janis Upeslacis, and Donald B. Borders The Mitomycins William A. Remers Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents Michelle Prudhomme Combinatorial Biosynthesis of Anticancer Natural Products Steven G. Van Lanen and Ben Shen Developments and Future Trends in Anticancer Natural Products Drug Discovery Gordon M. Cragg and David J. Newman Index