Drug Delivery Systems

ISBN: 9781439806180 出版年：2011 页码：594 Ranade, Vasant V Cannon, John B CRC Press

SITE-SPECIFIC DRUG DELIVERY Site-Specific Drug Delivery Using Liposomes as Carriers Introduction Liposomes in Drug Delivery The Liposome-Drug Concept Liposomes as Carriers of Therapeutic Agents Recent Advances Concluding Remarks Site Specific Drug Delivery Utilizing Monoclonal Antibodies Introduction Production of Monoclonal Antibodies Drug-Monoclonal Antibody Conjugates for Drug Targeting Recent Studies with Monoclonal Antibodies Conclusion and Basis for Future Trends References POLYMERS, IMPLANTABLE DRUG DELIVERY Role of Polymers in Drug Delivery Introduction Currently Available Polymers Soluble Polymers Biodegradable or Bioerodible Polymers Mucoadhesive Polymers Polymers Containing Pendant Substituents Matrix Systems Heparin Releasing Polymers Ionic Polymers Oligomers Miscellaneous Recent Advances Conclusion Implants in Drug Delivery Introduction Insulin Delivery as a Model Implant Pump System Implants for Contraception ORAL DRUG DELIVERY Oral Drug Delivery Introduction Features of the GI Tract Targeting of Drugs in the GI Tract Design and Fabrication of Oral Delivery systems Survey of Oral Controlled Release Products Recent Advances Conclusion References TRANSDERMANL, INTRANASAL, OCULAR, AND MISCELLANEOUS DRUG DELIVERY Transdermal Drug Delivery Introduction Structure of Human Skin Theoretical Advantages of the Transdermal Route Optimization of Percutaneous Absorption Theory for Penetration-Enhancer Activity Development of the Transdermal Therapeutic System Examples of Transdermal Applications Transdermal Controlled-Release Products and Devices Recent Advances Conclusion References Intranasal and Ocular Drug Delivery Intranasal Drug Delivery Ocular Drug Delivery References Miscellaneous Forms of Drug Delivery Introduction Prodrugs Infusion Devices Insulin Delivery Parenteral Prolonged Action Dosage Forms Summary REGULATORY CONSIDERATIONS AND GLOBAL OUTLOOK Regulatory Considerations for Drug Delivery Systems Introduction Current Status of Drug Delivery Technology Submission of Documents for Manufacture and Quality Drug Delivery Industry and the Global Outlook INDEX