Practical Aspects of Hyaluronan Based Medical Products

ISBN: 9780849333248 出版年：2005 页码：238 Kuo, J W CRC Press

OVERVIEW Discovery Primary Structure Molecular Formula Member of Glycosaminoglycans HA Structures of Higher Orders Viscosity, Molecular Weight, and Structures Source and Isolation Distribution and Catabolism Influence on Cell Behavior Chemical Modification HA-Based Medical Products Ever-Growing Interest References CHEMISTRY Chemistry in Structural Investigation Chromogenic Reactions Chemistry of HA Degradation Chemistry in Isotopic Labeling Synthesis of Fluorescent HA Biotinylated HA HA Derivatives with Various Side Chains HA-Drug Conjugation Chemical Crosslinking of HA Preparation of Oligosaccharides Sulfation of HA Summary of Methods of Chemical Modification References RHEOLOGICAL PROPERTIES OF HYALURONAN AS RELATED TO ITS STRUCTURE, SIZE, AND CONCENTRATION Some Basic Concepts of Intrinsic Viscosity Hydrodynamic Volume and Molecular Structures Absolute Viscosity Measured at Steady State Viscoelasticity References STANDARDS, TESTS, AND ANALYTICAL METHODS Standards and Specifications Analyses of HA Structure, Size, and Quantity Natural Polymeric Impurities Other Bioassays Lipoteichoic Acid Chemical Methods of Radiolabeling References SAFETY OF HYALURONAN-BASED MEDICAL PRODUCTS IN THEIR INDICATED APPLICATIONS General Safety Considerations Safety Information from Specific Human Use References CLINICAL PERFORMANCE, MECHANISM OF ACTION, AND PRODUCT CHARACTERISTICS Ophthalmic Surgeries Injections for Osteoarthritic Knees Adhesion Prevention and Wound Healing Tissue Augmentation Dental and Bone Application References INDEX