Knowledge Discovery in Proteomics

ISBN: 9780367392178 出版年：2005 页码：359 Jurisica, Igor Wigle, Dennis CRC Press

INTRODUCTION Knowledge Discovery Proteomics KNOWLEDGE MANAGEMENT Computational Analysis, Visualization, and Interpretation of HTP Proteomic Data Introduction to Data Management Knowledge Management Conclusions CURRENT STATUS AND FUTURE PROSPECTS OF MASS SPECTROMETRY Basic Concepts of Mass Spectrometry Multidimensional Chromatography Protein Quantitation Detection of Post-Translation Modifications Global Data Analysis, Informatics Resources, and Data Mining GRAPH THEORY ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS Graph Theoretic Terminology Biological Terminology Large Network Models Protein Interaction Networks Detection of Dense Subnetworks Conclusions HTP PROTEIN CRYSTALLIZATION APPROACHES Protein Crystallization Image Analysis in http Protein Crystallization Case-based Planning of Crystallization Experiments Protein Crystallization Knowledge Discovery Conclusions INTEGRATION OF DIVERSE DATA, ALGORITHMS, AND DOMAINS Integration of Data and Tools Characterizing and Predicting Protein-Protein Interactions Approaches to Data Integration Conclusions FROM HIGH-THROUGHPUT TO SYSTEMS BIOLOGY An Overview of Systems Biology Systematic Biology Protein-Protein Interactions Modular Biology from Protein Interaction Domains Protein Interaction Networks Theoretical Models of Biological Systems Software Development for System Modeling Cancer as a System Failure References