PREFACE AND ACKNOWLEDGMENTS INTENSITY-MODULATED RADIATION THERAPY (IMRT): GNERAL STATEMENTS AND POINTS OF DEBATE Observations on IMRT at the current time Criticism of the philosophy of IMRT DEVELOPMENTS IN ROTATION IMRT AND TOMOTHERAPY NOMOS MIMiC tomotherapy University of Wisconsin machine for tomotherapy Tomotherapy using a 60Co source Tomotherapy with an MLC Summary DEVELOPMENTS IN IMRT USING A MULTILEAF COLLIMATOR (MLC) New sequencers/interpreters Radiation leakage and accounting for machine effects in IMRT delivery Dose calculation for IMRT Features of MLC delivery of IMRT Dynamic arc therapy Combining step-and-shoot and dynamic delivery for dMLC IMAT-technical issues New ideas related to the dMLC technique Compensators and comparisons of compensator and MLC-based IMRT Optimum width of leaves for an MLC MicroMLCs for IMRT Increasing the spatial resolution of a conventional MLC Verification of MLC-delivered IMRT Quality assurance (QA) of MLC delivery Summary DEVELOPMENTS IN IMRT NOT USING AN MLC The Cyberknife The design of the shuttling MLC (SMLC) IMRT with the "jaws-plus-mask" technique The variable aperture collimator (VAC) One-dimensional IMRT Summary CLINICAL IMRT- EVIDENCE-BASED MEDICINE? IMRT of the prostate showing measurable clinical benefit Comparison of treatment techniques for the prostate Royal Marsden NHS Foundation Trust pelvic and other IMRT Comparison of IMRT with conformal radiotherapy (CFRT) for complex shaped tumors IMRT for whole-pelvic and gynecological radiotherapy Head-and-neck IMRT Breast IMRT Bladder IMRT at the Christie Hospital Lung cancer IMRT Scalp IMRT Other clinical IMRT reports-various tumor sites Summary 3D PLANNING FOR CFRT AND IMRT: DEVELOPMENTS IN IMAGING FOR PLANNING AND FOR ASSISTING THERAPY Challenges to IMRT and inverse planning Determination of the GTV, CTV, and PTV: the influence of 3D medical imaging New inverse-planning methods for IMRT New forward-planning methods for IMRT: direct aperture optimization Smoothing IMBs Incorporating MLC equipment constraints in inverse planning Beam direction optimization Monte Carlo dose calculation Energy in IMRT Measuring and accounting for patient/tumor movement Megavoltage CT (MVCT) and kilovoltage CT (kVCT) for position verification MRI and IMRT simultaneously IMRT using mixed photons and electrons EPILOGUE REFERENCES INDEX
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