Biomarkers of Environmentally Associated Disease —— Technologies, Concepts, and Perspectives

----- 环境相关疾病的生物标记

ISBN: 9781566705967 出版年：2002 页码：608 CRC Press

OVERVIEW Overview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health, William A. Suk and Samuel H. Wilson Ethical and Legal Considerations in Biological Markers Research, Richard Sharp and Paul Zigas Scientific and Policy Issues Affecting the Future of Environmental Health Sciences, Bernard Goldstein GENOMICS-BASED BIOMARKERS/GENETIC TOXICOLOGY BIOMARKERS Ecogenetics: Genetic Susceptibility to Environmental Adversity, Dan Nebert Toxicogenomics and Pharmacogenomics: Basic Principles, Potential Applications, and Issues, Peter Guengerich Individual Susceptibility to Exposures: A Role for Genetic Variation in DNA Repair Genes, Harvey W. Mohrenweiser Studies of DNA Repair and Human Cancer: An Update, Marianne Berwick, et al. DNA Adducts as Biomarkers of DNA Damage in Lung Cancer, S. Vulmiri and John DiGiovanni Tamoxifen-DNA Adducts: Biomarkers for Drug-Induced Endometrial Cancer, Shinya Shibutani, Naomi Suzuki, and Arthur Grollman Polycyclic Aromatic Hydrocarbon DNA Adducts and Human Cancer, Mikhail F. Denissenko, Moon-Shong Tang, and Gerd P. Pfeifer Quantitative PCR: A Sensitive Biomarker of Gene-Specific DNA Damage and Repair, Bennett Van Houten, Yiming Chen, Janine H. Santos, and Bhaskar S. Mandavilli Fidelity of DNA Synthesis as a Molecular Biomarker, Kandace Williams Mutational Specificity of Environmental Carcinogens, Kathleen Dixon and Mario Medvedovic BIOMARKERS OF METAL METABOLISM Learning-Induced Modulation of Neural Cell Adhesion Polysialytion State as a Biomarker of Prior Inorganic Lead Exposure During the Early Postnatal Period, Keith J. Murphy, Helen C. Gallagher, and Ciaran Regan Molecular Biomarkers for Mercury, Thomas Clarkson and Nazzareno Ballatori Validity of Mercury Exposure Biomarkers, Philippe Grandjean, Poul J. Jorgensen, and Pal Weile Urinary Arsenic Species in Relation to Drinking Water, Toenail Arsenic Concentrations and Genetic Polymorphisms in GSTM1 in New Hampshire, Maragaret Karagas, Heather H. Nelson, Karl T. Kelsey, Steven Morris, Joel D. Blum, Tor D. Tosteson, Mark Carey, Xiufen Lu, and X. Chris Le Molecular Responses of Mammalian Cells to Nickel and Chromate Exposure, Max Costa, Konstantin Salnikow, Jessica E. Sutherland, Thomas Kluz, Wu Peng, and Moon-Shong Tang Chromium: Exposure, Toxicity and Biomonitoring Approaches Anthony Zhitkovich Using Plankton Food Web Variables as Indicators for the Accumulation of Toxic Metals in Fish, Carol Folt, Celia Y. Chen, and Paul C. Pickhardt ORGAN & SYSTEMS BIOMARKERS Validation of Exposure and Risk Biomarkers: Aflatoxin as a Case Study, John Groopman, Peta E. Jackson, Paul Turner, Christopher P. Wild, and Thomas W. Kensler Biomarkers of Early Effect in the Study of Cancer Risk, Laura Gunn, Luoping Zhang, Matthew S. Forrest, Nina T. Holland, and Martyn T. Smith Proteomics in Toxicology - An Experience with Gentamicin, Sandy Kennedy, M.D. Kelly, C. Moyses, R. Ames, and R. Parekh Xenopus laevis Genomic Biomarkers for Environmental Toxicology Studies, Perry Blackshear Molecular Biomarkers Targeting Signal Transduction Systems: The AH Receptor Pathway, Timothy R. Fennell, Frederick J. Miller, and William Greenlee Measuring Oxidative Damage Caused by Environmental Stressors: Potential for Reversal and Abatement, Robert Floyd Biomarkers of Male Reproductive Health, Anne Golden Peripheral Benzodiazepine Receptors: Molecular Biomarkers of Neurotoxicity, Tomas R. Guilarte BIOMARKERS AND CHEMICAL TOXICANTS Biomarkers of Organic Injury from Chemical Exposure: Concurrent Inflammation as a Determinant of Susceptibility, Robert A. Roth and Patricia Ganey Modulation of GAP Junctional Communication by "Epigenetic" Toxicants: A Shared Mechanism in Teratogenesis, Carcinogenesis, Atherogenesis, Immunomodulation, Reproductive- and Neuro-Toxicities, James Trosko, Chia-Cheng Chang, and Brad Upham Exposure to POPs and Other Cogeners, Stephen Safe Polybrominated Diphenyl Ethers : Route, Dose, and Kinetics of Exposure to Humans, Ake Bergman, Lars Hagmar, Peter Hoglund, and Andreas Sjodin Bioanalytical Approaches for the Detection of Dioxin and Related Halogenated Aromatic Hydrocarbons, Michael Denison, Scott R. Nagy, Michael Ziccardi, George C. Clark, Michael Chu, David J. Brown, Guomin Shan, Yukio Sugawara, Shirley J. Gee, James Sanborn, and Bruce D, Hammock Application of Biomarkers to Population Studies on Food Chain Contaminants in Nunavik (Arctic Quebec, Canada), Eric Dewailly, Pierre Ayotte, Marc Rhainds, Suzanne Bruneau, Chris Furgal, Jacques Grondin, Benoit Levesque, Carole Blanchet, Daria Pereg, and Gina Muckle University-Community Partnership for the Study of Environmental Contamination at Akwesasne, David Carpenter, Alice Tarbell, Edward Fitzgerald, Michael J. Kadlec, David O'Hehir, and Brian Bush NANOTECHNIQUES & BIOMARKERS Electronic Biosensing, G.R. Facer, O.A. Saleh, D.A. Notterdam, and Lydia L. Sohn Two-Photon Fluorescence Microscopy: A Review of Recent Advances in Deep-Tissue Imaging, Chen-Yuan Dong, Lily Hsu, Ki-Hearn Kim, Christof Buehler, Peter D. Kaplan, Thomas D. Hancewicz, Peter T. C. So.