SECTION I Biofilms: Background, Significance, and Roles of Catheters and Indwelling Devices Microbial Biofilms Xiuping Jiang and John L. Pace Economic Impact of Biofilms on Treatment Costs John G. Thomas, Isaiah Litton, and Harald Rinde Biofilm-Related Indwelling Medical Device Infections Matthew K. Schinabeck and Mahmoud A. Ghannoum Medical Device Composition and Biological Secretion Influences on Biofilm Formation Sean P. Gorman and David S. Jones SECTION II Biofilm-Forming Pathogens Role of Biofilms in Infections Caused by Escherichia coli Gregory Jubelin, Corinne Dorel, and Philippe Lejeune Staphylococcus aureus Biofilms Julie M. Higashi and Paul M. Sullam Coagulase-Negative Staphylococci Dietrich Mack, Matthias A. Horstkotte, Holger Rohde, and Johannes K.-M. Knobloch Pseudomonas aeruginosa Biofilm Infections in Cystic Fibrosis Andrea Smiley and Daniel J. Hassett Candida Stephen Hawser and Khalid Islam SECTION III Emerging Issues, Assays, and Models Current Perspectives on the Regulation of the ica Operon and Biofilm Formation in Staphylococcus epidermidis Paul D. Fey and Luke D. Handke Cell-to-Cell Communication in Bacteria Kenneth D. Tucker and Luciano Passador Persisters: Specialized Cells Responsible for Biofilm Tolerance to Antimicrobial Agents Kim Lewis, Amy L. Spoering, Niilo Kaldalu, Iris Keren, and Devang Shah Minimal Biofilm Eradication Concentration (MBEC) Assay: Susceptibility Testing for Biofilms Howard Ceri, Merle E. Olson, Douglas W. Morck, and Douglas G. Storey Environmental Cues Regulate Virulence and Biofilm Formation John L. Pace and Steven M. Frey In Vivo Models for the Study of Biomaterial-Associated Infection by Biofilm-Forming Staphylococci Luke D. Handke and Mark E. Rupp Host Response to Biofilms Susan Meier-Davis SECTION IV Overview of Antiinfective Agents and Clinical Therapy Pharmacodynamics and the Treatment of IMD-Related Infections Roger Finch and Sarah Gander Protein Synthesis Inhibitors, Fluoroquinolones, and Rifampin for Biofilm Infections Steven L. Barriere *-Lactams for the Treatment of Biofilm-Associated Infections Ingrid L. Dodge, Karen Joy Shaw, and Karen Bush Glycopeptide Antibacterials and the Treatment of Biofilm-Related Infections John L. Pace, Roasaire Verna, and Jan Verhoef Antibiotic Resistance in Biofilms Nafsika H. Georgopapadakou Treatment Protocols for Infections of Vascular Catheters Russell E. Lewis and Issam I. Raad Treatment Protocols for Bacterial Endocarditis and Infection of Electrophysiologic Cardiac Devices Martin E. Stryjewski and G. Ralph Corey Treatment Protocol of Infections of Orthopedic Devices Vera Antonios, Elie Berbari, and Douglas Osmon Index ...
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