Introduction to Genomic Signal Processing with Control

ISBN: 9780849371981 出版年：2018 页码：302 Datta, Aniruddha Dougherty, Edward R CRC Press

INTRODUCTION REVIEW OF ORGANIC CHEMISTRY Electrovalent and Covalent Bonds Some Chemical Bonds and Groups Commonly Encountered in Biological Molecules Building Blocks for Common Organic Molecules ENERGY CONSIDERATIONS IN BIOCHEMICAL REACTIONS Some Common Biochemical Reactions Role of Enzymes Feasibility of Chemical Reactions Activated Carrier Molecules and Their Role in Biosynthesis PROTEINS Protein Structure and Function Levels of Organization in Proteins Protein Ligand Interactions Isolating Proteins from Cells Separating a Mixture of Proteins Protein Structure Determination Proteins That Are Enzymes DNA TRANSCRIPTION AND TRANSLATION Transcription Translation CHROMOSOMES AND GENE REGULATION Organization of DNA into Chromosomes Gene Regulation GENETIC VARIATION Genetic Variation in Bacteria Sources of Genetic Change in Eucaryotic Genomes DNA TECHNOLOGY Techniques for Analyzing DNA Molecules Nucleic Acid Hybridization and Associated Techniques Construction of Human Genomic and cDNA Libraries Polymerase Chain Reaction (PCR) Genetic Engineering CELL DIVISION Mitosis and Cytokinesis Meiosis CELL CYCLE CONTROL, CELL DEATH AND CANCER Cyclin-Dependent Kinases and Their Role Control of Cell Numbers in Multicellular Organisms Programmed Cell Death Cancer as the Breakdown of Cell Cycle Control EXPRESSION MICROARRAYS cDNA Microarrays Synthetic Oligonucleotide Arrays CLASSIFICATION Classifier Design Feature Selection Error Estimation CLUSTERING Examples of Clustering Algorithms Clustering Accuracy Cluster Validation GENETIC REGULATORY NETWORKS Nonlinear Dynamical Modeling of Gene Networks Boolean Networks Probabilistic Boolean Networks Network Inference INTERVENTION PBN Notation Intervention by Flipping the Status of a Single Gene Intervention to Alter the Steady-State Behavior EXTERNAL INTERVENTION BASED ON OPTIMAL CONTROL THEORY Finite Horizon Control External Intervention in the Imperfect Information Case External Intervention in the Context-Sensitive Case External Intervention for a Family of Boolean Networks External Intervention in the Infinite Horizon Case Concluding Remarks References Index