Biochemical Targets of Plant Bioactive Compounds —— A Pharmacological Reference Guide to Sites of Action and Biological Effects

----- 植物生物活性化合物的生化指标，药理参考指南，作用位点和生物效应

ISBN: 9780415308298 出版年：2003 页码：860 Polya, Gideon CRC Press

PLANT DEFENSIVE COMPOUNDS AND THEIR MOLECULAR TARGETS Introduction Organization and Scope of the Book Description of the Tables Using the Tables The Structural Diversity of Plant Defensive Compounds Plant Alkaloids Plant Phenolics Plant Terpenes Other Plant Compounds BIOCHEMISTRY - THE CHEMISTRY OF LIFE Introduction - Water-based Life Protein Structure Enzymes and Ligand-binding Proteins Metabolic Strategies Inhibition of Biochemical Processes by Plant Defensive Compounds NEUROTRANSMITTER- AND HORMONE-GATED ION CHANNELS Introduction - Electrical Signaling in Excitable Cells Ionotropic Neurotransmitter Receptors - Neurotransmitter-gated Ion Channels Structure and Function of Ionotropic Receptors ION PUMPS, LIGAND- AND VOLTAGE-GATED ION CHANNELS Introduction Ion Pumps Voltage-gated Na+ Channels Ligand-Regulated and Voltage-gated K+ Channels Voltage-gated Ca2+ Channels Ligand-gated Ca2+ Channels Chloride Transport and Voltage-regulated Chloride Channels PLASMA MEMBRANE G PROTEIN-COUPLED RECEPTORS Introduction - Signaling Via Heterotrimeric G Proteins G Protein-coupled Hormone and Neurotransmitter Receptors Hormones and Neurotransmitters Acting Via G Protein-coupled Receptors Activation of Specific G Protein-coupled Receptors Leucocyte- and Inflammation-related G Protein-linked Receptors Other G Protein-coupled Receptors NEUROTRANSMITTER TRANSPORTERS AND CONVERTERS Introduction Synthesis of Neurotransmitters Release of Neurotransmitters from Synaptic Vesicles Re-uptake of Neurotransmitters into Neurons and Synaptic Vesicles Neurotransmitter Degradation CYCLIC NUCLEOTIDE-, Ca2+- AND NITRIC OXIDE-BASED SIGNALING Introduction Ca2+- and Calmodulin-dependent Enzymes Adenylyl Cyclase Membrane-bound and Soluble Guanylyl Cyclases Nitric Oxide Synthesis Cyclic AMP- and Cyclic GMP-dependent Protein Kinases Protein Kinase Homologies and Phosphoprotein Phosphatases Cyclic Nucleotide Phosphodiesterases SIGNAL-REGULATED PROTEIN KINASES Introduction Cyclic AMP-dependent Protein Kinase Cyclic GMP-dependent Protein Kinase Protein Kinase C Ca2+ -calmodulin-dependent Protein Kinases AMP-dependent Protein Kinase Receptor Tyrosine Kinases Protein Kinase B Cytokine Activation of the JAK/STAT Pathway Cell Cycle Control Receptor Serine/Threonine Kinases Other Protein Kinases Phosphoprotein Phosphatases GENE EXPRESSION, CELL DIVISION AND APOPTOSIS Introduction Regulation of Gene Expression in Prokaryotes Regulation of Transcription in Eukaryotes RNA Processing and Translation Control of Translation Protein Processing and Post-translational Modification Protein Targeting Cell Division and Apoptosis HIV-1 Infection and HIV-1 Replication Plant Compounds Interfering with Gene Expression TASTE AND SMELL PERCEPTION, PHEROMONES AND SEMIOCHEMICALS Introduction Sweet Taste Receptors Bitter Taste Receptors Salty Taste Perception Sour Taste Perception Umami (Glutamate Taste Perception) Odorant Perception Animal Pheromones and Other Animal Bioactivities Produced by Plants Other Plant Semiochemicals Affecting Animal Behavior Odoriferous Animal Metabolites of Ingested Plant Compounds AGONISTS AND ANTAGONISTS OF CYTOSOLIC HORMONE RECEPTORS Introduction Steroid Hormones Non-steroid Cytosolic Hormone Receptor Ligands Plant Bioactives Affecting Cyctosolic Receptor-mediated Signaling POLYNUCLEOTIDES, POLYSACCHARIDES, PHOSPHOLIPIDS AND MEMBRANES Introduction Polynucleotides Polysaccharides and Oligosaccharides Phospholipids and Membranes INHIBITORS OF DIGESTION AND METABOLISM Introduction Glycohydrolases Proteases Glycolysis and Tricarboxylic Acid Cycle Mitochondrial Electron Transport and Oxidative Phosphorylation Gluconeogenesis Solute Translocation ANTI-INFLAMMATORY, ANTIOXIDANT AND ANTIDIABETIC PLANT COMPOUNDS Introduction Adhesion and Movement of Inflammatory Leucocytes Chemokines Phagocytosis Kinins, Cytokines, Platelet Activating Factor and Eicosanoids Plant-derived Anti-inflammatory Compounds Diabetes Mellitus and Plant Antidiabetic Compounds Summary Appendix Bibliography Compound Index Plant Genus Index Plant Common Names Index Subject Index Abbreviations