Drug Discovery Toxicology —— From Target Assessment to Translational Biomarkers

----- 药物发现毒理学:从目标评估转化生物标志物

ISBN: 9781119053330 出版年：2016 页码：601 Yvonne Will J Eric McDuffie Wiley

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful• Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools• Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods• Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices