Ribosome-inactivating Proteins —— Ricin and Related Proteins

----- 核糖体失活蛋白：蓖麻毒素与相关蛋白

ISBN: 9781118125656 出版年：2014 页码：326 Fiorenzo Stirpe Douglas Lappi Wiley

This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.