1. Clinical trial basics 2. Actionable prognostic biomarkers 3. Phase II designs 4. Enrichment designs 5. Including both test positive and test negative patients 6. Adaptive threshold design 7. Multiple predictive biomarkers predictive analysis of clinical trials 8. Prospective - retrospective design Appendix A. Statistics background Appendix B. Prognostic classifiers based on high dimensional data.
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