Separation Methods in Drug Synthesis and Purification

ISBN: 9780444640703 出版年：2020 页码：790 Elsevier Science_RM

Hardbound. The new technologies in drug research such as combinatorial chemistry, high throughput screening, and robotics have made it possible to synthesise millions of molecules for thousands of screens. This volume presents the theory and applications of a wide range of separation methods used in the early stages of drug synthesis, purification and characterisation.The topics covered are high performance liquid chromatography, capillary electrophoresis, capillary electro-chromatography, enantioseparations, preparative chromatography, and thin-layer chromatography. The separation methods used for the determination of physical-chemical properties together with the quantitative structure-retention relationship studies are also reviewed. The academic contributors provide a detailed description of the basic principles while the industrial contributors give real life examples of their application. The book not only reviews the major achievements i