The First Miracle Drugs —— How the Sulfa Drugs Transformed Medicine

Name: The First Miracle Drugs
Rating: 4.84
ISBN: 9780195187755

----- 第一种神奇药物：硫磺是如何变成药物的

ISBN: 9780195187755 出版年：2006 页码：377 Oxford University Press

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内容简介

In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II.

Amazon评论

Amazon Customer

Jack Lesch worked for years on this book and it shows. It is thoroughly researched and well written. It is not for the casual reader, however. You must be interested in the history of medicine, pharmacy, or science, and have some knowledge of those topics. If you want to understand the discovery and development of the sulfa drugs (and their play in the history of anti-microbials),this is the book for you.

B. Martin

An indispensable resource for anyone interested in early drug development and the dawn of pharmaceutical antibiosis. Notably Dr. Lesch has provided important insights into the seminal European development and investigation of sulfanilamide, the world's first widely distributed antibiotic. Lesch has thoroughly mined both the relevant corporate (Bayer) and academic (Pasteur Institute) archives to paint a much fuller and more nuanced picture of the collaborative and competitive scientific work that ultimately revolutionized the global practice of medicine. --Barbara J. Martin, MD, author, Elixir: The American Tragedy of a Deadly Drug

Amazon Customer

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