Evolution in Health and Disease

ISBN: 9780199207466 出版年：2010 页码：397 Oxford University Press

PART I: INTRODUCTION 1. Introducing evolutionary thinking 2. Research Designs that Address Evolutionary Questions about Medical Disorders PART II: HUMAN HISTORY AND HUMAN GENES 3. The history and geography of human genetic diversity 4. Medically relevant genetic variation of drug effects 5. Genetic variation and human disease: The role of natural selection 6. Human genetic variation and its impact on public health and medicine PART III: NATURAL SELECTION, CONFLICTS, AND CONSTRAINTS 7. Genetic conflicts of pregnancy and childhood 8. Human evolution and disease: putting the stone age in perspective 9. Pathogen-driven sexual selection and the evolution of health 10. Evolutionary interpretations of the diversity of reproductive health and disease PART IV: PATHOGENS, DRUGS AND VIRULENCE 11. The population biology of anti-infective chemotherapy and the evolution of drug resistance: more questions than answers 12. Development and use of vaccines against evolving pathogens: Vaccine design 13. Evolution of infectious diseases: the impact of vaccines, drugs and social factors 14. The evolution and expression of parasite virulence 15. Molecular phylogenies and the genetic structure of viral populations 16. The genetic population structure of pathogenic bacteria 17. Whole-genome analyses of pathogens 18. What can evolutionary biology contribute to understanding virulence? PART V. NONINFECTIOUS AND DEGENERATIVE DISEASE 20. An evolutionary perspective on the genetic architecture of susceptibility to cardiovascular disease 21. The fetal origins of coronary heart disease and stroke: evolutionary implications 22. The evolutionary context of chronic degenerative diseases 23. Testing evolutionary hypotheses about mental disorders 24. The evolution of non-infectious and degenerative disease