Protein Misfolding

ISBN: 9780128177501 出版年：2020 页码：452 Academic Press_Series

Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more.Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disordersContains timely chapters written by well-renowned authorities in their fieldProvides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students