Molecular Chaperones in Human Disorders

ISBN: 9780128155578 出版年：2019 页码：426 Academic Press_Series

Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining chromatin repair, the balance between chromosomal repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Chapters in this new release cover Functional principles and regulation of molecular chaperones, Chaperones and retinal disorders, Protein misfolding and degradation in genetic diseases, Chaperone dysfunction in hereditary myopathic diseases, Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulum, and many other timely topics. Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseasesProvides an ideal resource for a very wide audience of specialists, researchers and studentsContains timely chapters written by well-renown authorities in their fieldPresents information that is well supported by a number of high quality illustrations, figures and tables