Epigenetics in Human Disease

ISBN: 9780128122150 出版年：2018 页码：1,112 Academic Press_RM

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer disease, respiratory diseases, and many other human maladies.Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applicationsIntegrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughsPresents side-by-side coverage of the basis of epigenetic diseases and treatment pathwaysProvides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more