Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders —— Alzheimer's Disease

----- 用于治疗神经退行性疾病的药物发现途径：阿尔茨海默氏病

ISBN: 9780128028100 出版年：2016 页码：310 Academic Press_RM

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders.Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disordersExamines different classes of compounds currently being used in discovery and development stagesExplores in vitro and in vivo models with respect to their ability to translate these models to human conditionsDistills the most significant information across multiple areas of Alzheimer disease research to provide a single, comprehensive, and balanced resource