Translational Neuroimmunology in Multiple Sclerosis —— From Disease Mechanisms to Clinical Applications

----- 在多发性硬化症的转化神经免疫学：从疾病机制到临床应用

ISBN: 9780128019146 出版年：2016 页码：504 Academic Press_RM

Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon?such as neuroprotective strategies, stem cells, and repair promotion?are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatmentEdited by renowned leaders in the field of neuroimmunology and multiple sclerosisContains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology