Osteoimmunology —— Interactions of the Immune and Skeletal Systems

----- 骨免疫：互动免疫系统和骨骼系统

ISBN: 9780128005712 出版年：2015 页码：380 Academic Press_RM

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget disease, the genetics of bone disease, and bone cancer metastasis. Explains the intricate interaction between the immune system and boneFeatures detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systemsFacilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems