Historical background of the CR paradigm animal taxa studied study designs anti-aging action dietary factor mortality characteristics - survival curves and related data Gompertzian analyses age of initiation and duration of CR temporal pattern of food intake molecular and cellular biology stability of the nuclear genome - gene expression mitochondrial function membrane structure and function - protein signature, function and turnover cell proliferation - apoptosis cellular signal transduction organismic physiology - body composition nervous system locomotion and skeletal muscle cardiovascular system - endocrines and metabolism reproduction body temperature regulation immune function wound healing age-associated diseases cancer cardiovascular disease. (Part contents).
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